Hot Topics: adult, ass, free, girls, hot, love, low testosterone, penis, pussy, sex, testosterone, testosterone levels, women, Testofen, male sex organs, male sexual drive
December 6, 2008 | Filed Under Testosterone | No Comments
testosterone therapy
Low sex drive in women refers to a lack of interest in sexual relations. It is not unusual to experience a temporary decline in sexual desire at some point, and many women do. But if it persists, it may present problems.
The underlying reason for a decrease in sexual interest and activity, however, is not always obvious. Low sex drive can result from physical conditions (such as illness or pregnancy), psychological issues (such as stress or anxiety), or other factors. When a woman feels that her formerly normal sex drive has “stalled” or seems gone altogether, a medical or emotional problem may be at the root.
The signs of a low sex drive include:
Less frequent sexual thoughts and fantasies
- Reduced sexual desire
- Reluctance to initiate sex
- Less frequent masturbation
- Lack of desire for sex when you’ve gone without sex for days, weeks, or months (depending on what was previously normal for you)
In both men and women, sex drive is also referred to as libido.
What Testofen can Do for Low Libido
Researchers believe Testofens proposed methods of action are:
1. Testofen seems to have mode of action through the Adrenal Cortex. It seems to stimulate the secretion of Corticotropin Releasing Hormone [ CRH ] from the Hypothalamus in the brain.
2. The CRH reaches the Anterior Pituitary Gland and stimulates it to produce Adrenocorticotropic Hormone [ ACTH ]. ACTH then acts on the cells of the Adrenal Cortex stimulating them to produce Androgens. Androgens are precursors to Testosterone with Testosterone like activity, the common one being Androstenedione. Testosterone itself has 19 carbons and such a steroidal skeleton in general is called as an Androgenic Skeleton.
3. Testosterone and Androstenedione are interconvertible in our body, especially in the peripheral sites of action like muscles where Androstenedione converts more into Testosterone than the reverse.
4. Some amount of Testosterone gets converted into 5-Alpha DHT inthe body. Later, Testosterone, 5-Alpha-DHT and Androstenedione get metabolised in the GI tract and get flushed out of the system. Structural chart of this Androgen metabolism is shown below.
5. In sexually mature males, the quantity of such Testosterone produced through the ACT stimulation is much lower than in the testes to have much physiological significance.
6. But it helps in simulating Luteinizing Hormone [ LH ]secretion. LH is secreted by the pituitary glands in response tonegative feed back from Testosterone.
7. The negative feedback effect of Testosterone is actually produced by the conversion of Testosterone to 5-Alpha Reduced Androgens like 5-Alpha-DHT.
8. So LH then stimulates the Interstitial Cells of Leydig in the testes to produce Testosterone. Testosterone then produces 5-Alpha-DHT and the cycle goes on.
Testosterone has anabolic and androgenic activities. Anabolic Activity relates to role played in development of Muscle Mass. Androgenic Activity relates to role played in developmentof sexual characteristics of the human body like growth and development of male sex organs, male sexual drive and performance, spermatogenesisetc. Testofen has shown Testosterone boosting activity which leads to Anabolic and Androgenic activity consistent with the above hypothesis. Testofen seems to have Testosterone like properties on its own. It seems to bind to the Testosterone receptor sites in the body and seems to stimulate anabolic and androgenic activity. This has been verified by studies done on castrated male Swiss Wistar rats where in administration of Testofen has led to anabolic and androgenic activity similar to Testosterone.
